The Importance of Real-world Data: Outcomes of use of Direct-acting Oral Anticoagulants in Atrial Fibrillation
The Importance of Real-world Data: Outcomes of use of Direct-acting Oral Anticoagulants in Atrial Fibrillation Yeela Talmor-Barkan, Nancy-Sarah Yacovzada, Hagai Rossman, Guy Witberg, Iris Kalka, Ran Kornowski, Eran Segal, Head-to-head efficacy and safety of rivaroxaban, apixaban, and dabigatran in an observational nationwide targeted trial, European Heart Journal - Cardiovascular Pharmacotherapy , Volume 9, Issue 1, January 2023, Pages 26–37, https://doi.org/10.1093/ehjcvp/pvac063 Key findings Treatment with rivaroxaban was associated with decreased rates of all-cause mortality, ischaemic stroke, and intracranial bleeding compared with apixaban. Rivaroxaban compared with dabigatran demonstrated decreased rate of all-cause mortality and ischaemic stroke in patients under the age of 70 years, and decreased rate of intracranial haemorrhage in patients aged 80 years or above. Rivaroxaban was associated with increased gastrointestinal bleeding compared with apixaban. DT’s P...