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Potential effects of icosapent ethyl on cardiovascular outcomes in cigarette smokers: REDUCE-IT smoking Read all about it! In the March 2023 edition of EHJ CV Pharmacotherapy Journal - Subgroup analysis of REDUCE-IT, looking at how icosapent ethyl mitigates cardiovascular risk in smokers, ex-smokers and never smokers. My personal opinion is, wouldn’t it increase the cost for smokers, on top of their tobacco buying habits? Not sure of the message we will paint for them, like, “Hey Mr A, because you are smoking still, I’d like to give you some of these omega 3 fatty acid to reduce risk of recurrent heart attack. By the way, best to stop smoking though.”  ❓What do you think? How do we apply clinical trial findings sensibly in the real world? 👉🏻(Caveat: Subgroup Analyses should not be used to make clinical decisions, just thought to discuss these findings) #omega3fattyacids #reducedcardiovascularrisk #cardiology #smoking #heartdisease Michael Miller, Deepak L Bhatt, Ph Gabriel Steg, ...

The Importance of Real-world Data: Outcomes of use of Direct-acting Oral Anticoagulants in Atrial Fibrillation

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The Importance of Real-world Data:  Outcomes of use of Direct-acting Oral Anticoagulants in Atrial Fibrillation Yeela Talmor-Barkan, Nancy-Sarah Yacovzada, Hagai Rossman, Guy Witberg, Iris Kalka, Ran Kornowski, Eran Segal, Head-to-head efficacy and safety of rivaroxaban, apixaban, and dabigatran in an observational nationwide targeted trial,  European Heart Journal - Cardiovascular Pharmacotherapy , Volume 9, Issue 1, January 2023, Pages 26–37,  https://doi.org/10.1093/ehjcvp/pvac063 Key findings Treatment with rivaroxaban was associated with decreased rates of all-cause mortality, ischaemic stroke, and intracranial bleeding compared with apixaban. Rivaroxaban compared with dabigatran demonstrated decreased rate of all-cause mortality and ischaemic stroke in patients under the age of 70 years, and decreased rate of intracranial haemorrhage in patients aged 80 years or above. Rivaroxaban was associated with increased gastrointestinal bleeding compared with apixaban. DT’s P...